1.
feeling deeply moved, touched
Describes the warm, emotional sensation of being deeply moved or touched by something. Often accompanied by tears welling up.
2.
tingling, numbness, throbbing
Describes a physical sensation of tingling, numbness, or a dull aching, as from cold, a hit, or a wound.
Usage
The emotional sense (being moved) and the physical sense (tingling/numbness) both describe a deep, spreading sensation. Context makes the intended meaning clear — 胸がジーンとする is emotional, while 手がジーンとする is physical.
Common patterns
- ジーンとする: to feel moved (sense 1); to tingle (sense 2)
- ジーンとくる: to be moved, to feel it hit home (sense 1)