1.
cause and effect, causation
The relationship between causes and their results. Used in both philosophical/scientific and Buddhist contexts.
2.
karma, fate, retribution
From the Buddhist concept that past actions determine present circumstances. Often carries a negative nuance, suggesting misfortune brought about by past deeds.
Derived from the Buddhist concept of 因 (cause) and 果 (effect/result). In modern Japanese, sense 1 is used in academic and scientific contexts, while sense 2 retains the original Buddhist connotation.