1.
specialty, forte, strong point
Something one is good at or skilled in, with the polite prefix お.
2.
regular customer, valued customer, patron
A customer who frequently does business with a shop or company.
お得意 has two distinct meanings depending on context.
SENSE 1 (specialty):
Polite form of 得意 (strong point). Used when asking about or praising someone's skills.
SENSE 2 (customer):
Often appears as お得意さま or お得意さん.
- お得意さま: valued customer (formal/business)
- お得意さん: regular customer (casual)