1.
cross; crucifix
The Christian cross or crucifix as a religious symbol. Also refers to the physical object.
2.
burden; cross to bear
Used figuratively to mean a heavy burden or responsibility that one must endure.
Usage
Sense 1 is the literal religious object. Sense 2 is a figurative extension meaning a heavy burden or guilt, similar to the English expression "cross to bear." The figurative use is common in literary and dramatic contexts.