1.
route, path, course
A way or course taken to get from one place to another, such as a hiking trail, driving route, or travel itinerary.
2.
channel, pipeline, connection
A means or channel through which something is obtained or distributed, such as a supply route or a personal connection used to acquire something.
Usage
ルート is broadly used for both physical paths and abstract channels. For physical travel, it overlaps with 道 and 経路, but ルート emphasizes a planned or chosen course rather than just a road.
Sense 2 (channel/pipeline) is common in business and often implies a special or exclusive connection.