1.
three-dimensional; 3D
Having or appearing to have length, width, and depth. Used in science, technology, and everyday language.
2.
real; real-world (as opposed to fictional/2D)
In otaku culture, refers to the real world and real people, as opposed to the two-dimensional world of anime, manga, and games.
Usage
In technical contexts, refers to 3D space or 3D technology. In internet and otaku culture, 三次元 (3D, real world) contrasts with 二次元 (2D, anime/manga world). This slang usage is widely understood in Japan.